ECUST Researchers Report New Progress in Chiral Palladium Catalyst Development in the Journal of the American Chemical Society

Recently, the research group led by Professor Zhipeng Zhang and Dr. Shouyi Cen at the Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, ECUST, has developed a novel confined chiral palladium(II) catalyst, marking a significant step forward in enantioselective catalytic synthesis. The study, titled “Confined Chiral Pd(II) Catalyst-Enabled Enantioselective Intramolecular Aminoalkylation of Alkenes: One-Step Construction of Chiral N-Fused Bicyclic Skeletons”, was recently published in the prestigious Journal of the American Chemical Society. Doctoral candidate Yayun Chen from ECUST is the first author. 

The team received academic guidance from Academicians Kuiling Ding (Shanghai Institute of Organic Chemistry, CAS / Shanghai Jiao Tong University), He Tian (ECUST), and Weihong Zhu (ECUST). Additionally, Professor Yuanyuan Zhu from Hefei University of Technology assisted with single-crystal characterization and structural analysis. 

This work was supported by the National High-level Talent Program, the National Natural Science Foundation of China, the Fundamental Research Funds for the Central Universities, the Shanghai Natural Science Foundation, the Shanghai Postdoctoral Excellence Program, the Frontiers Science Center for Materiobiology and Dynamic Chemistry, and the Feringa Nobel Prize Scientist Joint Research Center, among other funding sources.